Selank

Name: Selank
Brand: GenDarwin Research
SKU: GD-SELANK
Price: 59.00 USD
Availability: BackOrder

Synthetic Tuftsin Derivative — H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH (TP-7)

$59.00 $11.80 / mg On backorder — dispatches in 5–10 business days

Lyophilized powder HPLC purity 99.43% Research use only

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro; TP-7) is a synthetic heptapeptide derived from the immunomodulatory tetrapeptide tuftsin, C-terminally extended with Pro-Gly-Pro to enhance metabolic stability. Research has characterised Selank as a modulator of GABA-A receptor subunit gene expression (α1, β1, β2, γ2), enkephalin-degrading enzyme inhibition, and BDNF upregulation in cortical neuron models. Preclinical studies have examined monoaminergic neurotransmitter dynamics, pro-inflammatory cytokine modulation (IL-6, TNF-α, TGF-β), and amygdala–prefrontal cortical functional connectivity in pharmacological research paradigms.

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PROPERTIES
Molecular Formula	C₃₃H₅₇N₁₁O₉
Molecular Weight (g/mol)	751.9
Monoisotopic Mass (Da)	751.4341
Topological Polar Surface Area (Å²)	322
Complexity	1360
XLogP (octanol-water partition)	-6.1
Heavy Atom Count	53
H-Bond Donor Count	9
H-Bond Acceptor Count	12
Rotatable Bond Count	19
InChIKey	JTDTXGMXNXBGBZ-YVHUGQOKSA-N
PubChem CID	11765600

All values above are taken from PubChem CID 11765600 and can be checked against that record.

2D Structure

CHEMICAL IDENTIFIERS
CAS Number	129954-34-3
PubChem CID	11765600
IUPAC Name	(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid
InChIKey	`JTDTXGMXNXBGBZ-YVHUGQOKSA-N`
InChI	`InChI=1S/C33H57N11O9/c1-19(45)26(35)29(49)41-20(8-2-3-13-34)30(50)44-17-6-11-23(44)28(48)40-21(9-4-14-38-33(36)37)31(51)43-16-5-10-22(43)27(47)39-18-25(46)42-15-7-12-24(42)32(52)53/h19-24,26,45H,2-18,34-35H2,1H3,(H,39,47)(H,40,48)(H,41,49)(H,52,53)(H4,36,37,38)/t19-,20+,21+,22+,23+,24+,26+/m1/s1`
SMILES	`C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N3CCC[C@H]3C(=O)O)N)O`

Identifiers retrieved from PubChem CID 11765600.

HPLC purity report Sample lot

Selank

Lot: P230424-LR271657
SKU: GD-SELANK

99.43% main peak, area %

12.385 minMain peak retention

0.5618%All other peaks

0.4719%Largest single impurity

4Peaks integrated

Drawn from the integration table below. Each peak sits at its reported retention time and is scaled so its height and area match the report; the peak shape is modelled and the baseline is flat, so this represents the reported integration rather than the raw detector file. Only the peaks the report lists are drawn. The lighter trace is the same data at 50× vertical zoom, because the impurity peaks are a fraction of a percent of the main peak.

Integration table as reported

#	Ret. time	Height	Area	Area %
1	11.505	3664.564	27757.322	0.4719
2	12.102	352.381	902.159	0.0153
3	12.385	401536.656	5848879.000	99.4381
4	14.193	653.359	4389.738	0.0746

Retention time in minutes. Height and area are the report’s own values and units. Method wording is normalised for units and spelling; every value is as reported.

Method as reported

Column	250 × 4.6 mm, Kromasil-C18-5 µm
Mobile phase A	0.1% TFA in water
Mobile phase B	0.1% TFA in acetonitrile
Flow rate	1.0 mL/min
Detection	220 nm
Injection volume	10 µL

Time	A	B
0.1min	93%	7%
25.0min	68%	32%
25.1min	0%	100%
30.0min	Stop

Identity verified against PubChem, not a measurement of this lot

CAS number: 129954-34-3
Molecular formula: C₃₃H₅₇N₁₁O₉
Molecular weight: 751.87 g/mol
Monoisotopic mass: 751.4341 Da
InChIKey: JTDTXGMXNXBGBZ-YVHUGQOKSA-N
PubChem CID: 11765600

Sample lot. This is the report supplied with the sample of this compound. A production lot ships with its own report, published here in the same form and indexed by its own lot number.

Every analytical figure above is transcribed from the supplier’s report for lot P230424-LR271657. Identity is the PubChem record, which can be checked independently. Purity is the main peak’s share of integrated peak area at the detection wavelength, so it measures related impurities. Water, salts and counter-ions are not part of it. These are the supplier’s release documents, not independent third-party tests.

This product is sold exclusively for in vitro and laboratory research use. It has not been evaluated by the FDA. Not approved for diagnostic, therapeutic, or veterinary use.

Selank

2D Structure

Integration table as reported

Method as reported

Identity verified against PubChem, not a measurement of this lot

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