PT-141

Name: PT-141
Brand: GenDarwin Research
SKU: GD-PT141
Price: 69.00 USD
Availability: BackOrder

Bremelanotide — Melanocortin Receptor Agonist [Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-Lys)-OH]

$69.00 $6.90 / mg On backorder — dispatches in 5–10 business days

Lyophilized powder HPLC purity 98.89% Research use only

PT-141 (Bremelanotide; Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH) is a synthetic cyclic heptapeptide differing from Melanotan II solely by a free C-terminal carboxylic acid rather than a primary amide. It acts as a non-selective agonist at MC1R, MC3R, and MC4R with documented activity in central hypothalamic and limbic melanocortin pathways. Research has characterised its receptor binding kinetics, ligand selectivity across MC1R–MC5R subtypes, cAMP signalling dynamics, and neuropeptide-driven transcriptional responses in neuronal and transfected cell model systems.

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PROPERTIES
Molecular Formula	C₅₀H₆₈N₁₄O₁₀
Molecular Weight (g/mol)	1025.2
Monoisotopic Mass (Da)	1024.5243
Topological Polar Surface Area (Å²)	379
Complexity	1950
XLogP (octanol-water partition)	0.7
Heavy Atom Count	74
H-Bond Donor Count	13
H-Bond Acceptor Count	12
Rotatable Bond Count	17
InChIKey	FFHBJDQSGDNCIV-MFVUMRCOSA-N
PubChem CID	9941379

All values above are taken from PubChem CID 9941379 and can be checked against that record.

2D Structure

CHEMICAL IDENTIFIERS
CAS Number	189691-06-3
PubChem CID	9941379
IUPAC Name	(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxylic acid
InChIKey	`FFHBJDQSGDNCIV-MFVUMRCOSA-N`
InChI	`InChI=1S/C50H68N14O10/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25H2,1-2H3,(H,53,57)(H,54,66)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,64,67)(H,73,74)(H4,51,52,55)/t35-,36-,37-,38+,39-,40-,41-/m0/s1`
SMILES	`CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)O)NC(=O)C`

Identifiers retrieved from PubChem CID 9941379.

HPLC purity report Sample lot

PT-141

Lot: P260711-LR056212
SKU: GD-PT141

98.89% main peak, area %

8.838 minMain peak retention

1.1098%All other peaks

0.6644%Largest single impurity

3Peaks integrated

Drawn from the integration table below. Each peak sits at its reported retention time and is scaled so its height and area match the report; the peak shape is modelled and the baseline is flat, so this represents the reported integration rather than the raw detector file. Only the peaks the report lists are drawn. The lighter trace is the same data at 50× vertical zoom, because the impurity peaks are a fraction of a percent of the main peak.

Integration table as reported

#	Ret. time	Height	Area	Area %
1	8.393	6251	68589	0.6644
2	8.838	807695	10209095	98.89
3	9.196	4711	45978	0.4454

Retention time in minutes. Height and area are the report’s own values and units. Method wording is normalised for units and spelling; every value is as reported.

Method as reported

Column	Sinochrom ODS-BP-5 C18, 4.6 × 250 mm, 5 µm
Mobile phase A	0.1% trifluoroacetic acid in acetonitrile
Mobile phase B	0.1% trifluoroacetic acid in water
Flow rate	1.0 mL/min
Detection	220 nm
Injection volume	20 µL

Time	A	B
0.0min	30%	70%
25.0min	55%	45%
25.1min	100%	0%
30.0min	Stop

Identity verified against PubChem, not a measurement of this lot

CAS number: 189691-06-3
Molecular formula: C₅₀H₆₈N₁₄O₁₀
Molecular weight: 1025.2 g/mol
Monoisotopic mass: 1024.5243 Da
InChIKey: FFHBJDQSGDNCIV-MFVUMRCOSA-N
PubChem CID: 9941379

Corrections and queries 1 corrected

Field	On the supplier document	Here	Why
CAS number	32780-32-8	189691-06-3	32780-32-8 belongs to validamine, a different compound. 189691-06-3 is bremelanotide and matches the sequence printed on the report, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH.

A measured result is never rewritten. Where a reported figure does not stand up, it is shown as printed and marked as queried.

Sample lot. This is the report supplied with the sample of this compound. A production lot ships with its own report, published here in the same form and indexed by its own lot number.

Every analytical figure above is transcribed from the supplier’s report for lot P260711-LR056212. Identity is the PubChem record, which can be checked independently. Purity is the main peak’s share of integrated peak area at the detection wavelength, so it measures related impurities. Water, salts and counter-ions are not part of it. These are the supplier’s release documents, not independent third-party tests.

This product is sold exclusively for in vitro and laboratory research use. It has not been evaluated by the FDA. Not approved for diagnostic, therapeutic, or veterinary use.

PT-141

2D Structure

Integration table as reported

Method as reported

Identity verified against PubChem, not a measurement of this lot

Corrections and queries 1 corrected

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