KPV

Name: KPV
Brand: GenDarwin Research
SKU: GD-KPV
Price: 59.00 USD
Availability: BackOrder

Lys-Pro-Val — C-terminal Tripeptide of α-Melanocyte-Stimulating Hormone

$59.00 $11.80 / mg On backorder — dispatches in 5–10 business days

Lyophilized powder HPLC purity 98.45% Research use only

KPV (Lys-Pro-Val) is a synthetic tripeptide corresponding to C-terminal residues 11–13 of α-melanocyte-stimulating hormone (α-MSH). Experimental studies have characterised KPV-mediated inhibition of NF-κB p65 nuclear translocation, attenuation of IκBα phosphorylation and degradation, and reduction of TNF-α-, IL-1β-, and IL-6-driven cytokine secretion in intestinal epithelial and macrophage systems. Cellular internalisation has been associated with the PepT1 (SLC15A1) oligopeptide transporter, upregulated in inflamed epithelium. Applied in cytokine signalling, epithelial barrier integrity, and NLRP3 inflammasome biology research.

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PROPERTIES
Molecular Formula	C₁₆H₃₀N₄O₄
Molecular Weight (g/mol)	342.43
Monoisotopic Mass (Da)	342.2267
Topological Polar Surface Area (Å²)	139
Complexity	455
XLogP (octanol-water partition)	-3.5
Heavy Atom Count	24
H-Bond Donor Count	4
H-Bond Acceptor Count	6
Rotatable Bond Count	9
InChIKey	YSPZCHGIWAQVKQ-AVGNSLFASA-N
PubChem CID	125672

All values above are taken from PubChem CID 125672 and can be checked against that record.

2D Structure

CHEMICAL IDENTIFIERS
CAS Number	67727-97-3
PubChem CID	125672
IUPAC Name	(2S)-2-[[(2S)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoic acid
InChIKey	`YSPZCHGIWAQVKQ-AVGNSLFASA-N`
InChI	`InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1`
SMILES	`CC(C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N`

Identifiers retrieved from PubChem CID 125672.

HPLC purity report Sample lot

KPV

Lot: P260709-YS194722
SKU: GD-KPV

98.45% main peak, area %

10.09 minMain peak retention

1.5498%All other peaks

0.5207%Largest single impurity

6Peaks integrated

Drawn from the integration table below. Each peak sits at its reported retention time and is scaled so its height and area match the report; the peak shape is modelled and the baseline is flat, so this represents the reported integration rather than the raw detector file. Only the peaks the report lists are drawn. The lighter trace is the same data at 20× vertical zoom, because the impurity peaks are a fraction of a percent of the main peak.

Integration table as reported

#	Ret. time	Height	Area	Area %
1	8.560	202.477	2477.304	0.0293
2	9.455	6149.191	44062.508	0.5207
3	9.845	5253.143	43052.711	0.5087
4	10.090	717738.125	8331782.000	98.4502
5	10.090	14890.150	39473.395	0.4664
6	11.670	264.287	2089.645	0.0247

Retention time in minutes. Height and area are the report’s own values and units. Method wording is normalised for units and spelling; every value is as reported.

Method as reported

Column	250 × 4.6 mm, ChromCore 120 C18 5 µm
Mobile phase A	0.1% TFA in water
Mobile phase B	0.1% TFA in acetonitrile
Flow rate	1.0 mL/min
Detection	220 nm
Injection volume	10 µL

Time	A	B
0.1min	95%	5%
25.0min	70%	30%
25.1min	0%	100%
30.0min	Stop

Identity verified against PubChem, not a measurement of this lot

CAS number: 67727-97-3
Molecular formula: C₁₆H₃₀N₄O₄
Molecular weight: 342.43 g/mol
Monoisotopic mass: 342.2267 Da
InChIKey: YSPZCHGIWAQVKQ-AVGNSLFASA-N
PubChem CID: 125672

Corrections and queries 0 corrected, 1 queried with the supplier

Field	On the supplier document	Here	Why
Peak table	peaks 4 and 5 both at 10.090 min	shown as reported, queried	Two peaks cannot share one apex time. It reads as one peak split by the integration software. Splitting it lowers the reported purity rather than raising it, so the figure is conservative either way, and we have asked the supplier to confirm the integration.

A measured result is never rewritten. Where a reported figure does not stand up, it is shown as printed and marked as queried.

Sample lot. This is the report supplied with the sample of this compound. A production lot ships with its own report, published here in the same form and indexed by its own lot number.

Every analytical figure above is transcribed from the supplier’s report for lot P260709-YS194722. Identity is the PubChem record, which can be checked independently. Purity is the main peak’s share of integrated peak area at the detection wavelength, so it measures related impurities. Water, salts and counter-ions are not part of it. These are the supplier’s release documents, not independent third-party tests.

This product is sold exclusively for in vitro and laboratory research use. It has not been evaluated by the FDA. Not approved for diagnostic, therapeutic, or veterinary use.

KPV

2D Structure

Integration table as reported

Method as reported

Identity verified against PubChem, not a measurement of this lot

Corrections and queries 0 corrected, 1 queried with the supplier

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