Thymosin alpha-1

Name: Thymosin alpha-1
Brand: GenDarwin Research
SKU: GD-TA1
Price: 89.00 USD
Availability: BackOrder

Thymalfasin — N-Terminally Acetylated 28-Residue Thymic Peptide (Prothymosin α Fragment)

$89.00 $17.80 / mg On backorder — dispatches in 5–10 business days

Lyophilized powder HPLC purity 98.54% Research use only

Thymosin Alpha-1 (Tα1; thymalfasin) is a 28-amino-acid N-terminally acetylated polypeptide originally isolated from bovine thymic fraction 5. N-terminal acetylation is critical for biological activity and metabolic stability. Research has characterised Tα1-associated activation of TLR9, TLR2, and TLR4 innate immune signalling via MyD88/NF-κB and TRIF-dependent cascades, dendritic cell maturation, MHC class II upregulation, T-lymphocyte differentiation, CD4⁺/CD8⁺ subset modulation, NK cell cytolytic enhancement, and thymic epithelial gene expression profiling in immune-oncology and vaccine adjuvant research models.

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PROPERTIES
Molecular Formula	C₁₂₉H₂₁₅N₃₃O₅₅
Molecular Weight (g/mol)	3108.3
Monoisotopic Mass (Da)	3106.5041
Topological Polar Surface Area (Å²)	1460
Complexity	7190
XLogP (octanol-water partition)	-24
Heavy Atom Count	217
H-Bond Donor Count	49
H-Bond Acceptor Count	59
Rotatable Bond Count	111
InChIKey	NZVYCXVTEHPMHE-ZSUJOUNUSA-N
PubChem CID	16130571

All values above are taken from PubChem CID 16130571 and can be checked against that record.

2D Structure

CHEMICAL IDENTIFIERS
CAS Number	62304-98-7
PubChem CID	16130571
IUPAC Name	(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-6-aminohexanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-5-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-5-oxopentanoic acid
InChIKey	`NZVYCXVTEHPMHE-ZSUJOUNUSA-N`
InChI	InChI=1S/C129H215N33O55/c1-18-59(10)98(159-114(201)76(36-42-91(181)182)146-120(207)83(53-164)154-121(208)84(54-165)155-127(214)99(63(14)166)160-118(205)80(51-94(187)188)152-123(210)95(56(4)5)156-104(191)62(13)135-102(189)60(11)137-115(202)78(49-92(183)184)151-119(206)82(52-163)138-66(17)169)125(212)161-101(65(16)168)128(215)162-100(64(15)167)126(213)147-70(30-22-26-46-133)109(196)150-79(50-93(185)186)117(204)149-77(47-55(2)3)116(203)142-69(29-21-25-45-132)108(195)144-73(33-39-88(175)176)110(197)141-67(27-19-23-43-130)106(193)140-68(28-20-24-44-131)107(194)145-75(35-41-90(179)180)113(200)157-97(58(8)9)124(211)158-96(57(6)7)122(209)148-74(34-40-89(177)178)111(198)143-71(31-37-86(171)172)105(192)136-61(12)103(190)139-72(32-38-87(173)174)112(199)153-81(129(216)217)48-85(134)170/h55-65,67-84,95-101,163-168H,18-54,130-133H2,1-17H3,(H2,134,170)(H,135,189)(H,136,192)(H,137,202)(H,138,169)(H,139,190)(H,140,193)(H,141,197)(H,142,203)(H,143,198)(H,144,195)(H,145,194)(H,146,207)(H,147,213)(H,148,209)(H,149,204)(H,150,196)(H,151,206)(H,152,210)(H,153,199)(H,154,208)(H,155,214)(H,156,191)(H,157,200)(H,158,211)(H,159,201)(H,160,205)(H,161,212)(H,162,215)(H,171,172)(H,173,174)(H,175,176)(H,177,178)(H,179,180)(H,181,182)(H,183,184)(H,185,186)(H,187,188)(H,216,217)/t59-,60-,61-,62-,63+,64+,65+,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,95-,96-,97-,98-,99-,100-,101-/m0/s1
SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)C

Identifiers retrieved from PubChem CID 16130571.

HPLC purity report Sample lot

Thymosin alpha-1

Lot: P260819-LR502108
SKU: GD-TA1

98.54% main peak, area %

11.444 minMain peak retention

1.4573%All other peaks

0.9469%Largest single impurity

3Peaks integrated

Drawn from the integration table below. Each peak sits at its reported retention time and is scaled so its height and area match the report; the peak shape is modelled and the baseline is flat, so this represents the reported integration rather than the raw detector file. Only the peaks the report lists are drawn. The lighter trace is the same data at 20× vertical zoom, because the impurity peaks are a fraction of a percent of the main peak.

Integration table as reported

#	Ret. time	Height	Area	Area %
1	10.777	6523	43893	0.5104
2	11.444	840896	8474136	98.55
3	11.746	14237	81422	0.9469

Retention time in minutes. Height and area are the report’s own values and units. Method wording is normalised for units and spelling; every value is as reported.

Method as reported

Column	250 × 4.6 mm, Kromasil-C18-5 µm
Mobile phase A	0.1% TFA in water
Mobile phase B	0.1% TFA in acetonitrile
Flow rate	1.0 mL/min
Detection	220 nm
Injection volume	5 µL

Time	A	B
0.1min	82%	18%
25.0min	57%	43%
25.1min	0%	100%
30.0min	Stop

Identity verified against PubChem, not a measurement of this lot

CAS number: 62304-98-7
Molecular formula: C₁₂₉H₂₁₅N₃₃O₅₅
Molecular weight: 3108.3 g/mol
Monoisotopic mass: 3106.5041 Da
InChIKey: NZVYCXVTEHPMHE-ZSUJOUNUSA-N
PubChem CID: 16130571

Corrections and queries 2 corrected

Field	On the supplier document	Here	Why
Purity figure	98.55%	98.54%	The report's own peak areas give 8,474,136 of 8,599,451, which is 98.5428%. 98.55% is that figure rounded up. We never publish a purity above what the printed areas give, so it is truncated rather than rounded.
Compound name	Tymosin alpha1 Acetate	Thymosin alpha-1	Spelling. The printed name corresponds to thymalfasin, CAS 62304-98-7, and the document also records the acetate salt form. This page is a purity chromatogram: it carries no identity test, so the identity shown below is the PubChem record rather than anything the report measured.

A measured result is never rewritten. Where a reported figure does not stand up, it is shown as printed and marked as queried.

Sample lot. This is the report supplied with the sample of this compound. A production lot ships with its own report, published here in the same form and indexed by its own lot number.

Every analytical figure above is transcribed from the supplier’s report for lot P260819-LR502108. Identity is the PubChem record, which can be checked independently. Purity is the main peak’s share of integrated peak area at the detection wavelength, so it measures related impurities. Water, salts and counter-ions are not part of it. These are the supplier’s release documents, not independent third-party tests.

This product is sold exclusively for in vitro and laboratory research use. It has not been evaluated by the FDA. Not approved for diagnostic, therapeutic, or veterinary use.

Thymosin alpha-1

2D Structure

Integration table as reported

Method as reported

Identity verified against PubChem, not a measurement of this lot

Corrections and queries 2 corrected

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