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GenDarwin Research Cagrilintide lyophilized research peptide vial, CAS 1415456-99-3

99.23%HPLC purity, as reported for this lot

COAPublished for lot DL26082102

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Cagrilintide

Name: Cagrilintide
Brand: GenDarwin Research
SKU: GD-CAGR
Price: 129.00 USD
Availability: BackOrder

Long-Acting Acylated Amylin Analogue — AMY Receptor / Calcitonin Receptor Agonist (NN9838)

$129.00 $25.80 / mg On backorder — dispatches in 5–10 business days

Lyophilized powder HPLC purity 99.23% Research use only

Cagrilintide (NN9838) is a long-acting synthetic amylin analogue incorporating Pro substitutions at positions 25, 28, and 29 to impede β-sheet fibril formation, a 14E/17R salt-bridge stabilising the central α-helix, and a C20 fatty diacid N-terminal lipid for albumin-mediated extended half-life (~7–8 days). It acts as a non-selective agonist at AMY1R, AMY2R, AMY3R, and CTR, activating adenylyl cyclase and cAMP-mediated signalling. Research has characterised cagrilintide in hypothalamic appetite-regulatory circuits, area postrema satiety pathways, and combinatorial metabolic endpoints in co-administration study designs.

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PROPERTIES
Molecular Formula	C₁₉₄H₃₁₂N₅₄O₅₉S₂
Molecular Weight (g/mol)	4409
Monoisotopic Mass (Da)	4406.2515
Topological Polar Surface Area (Å²)	1880
Complexity	10800
XLogP (octanol-water partition)	-12.5
Heavy Atom Count	309
H-Bond Donor Count	60
H-Bond Acceptor Count	65
Rotatable Bond Count	137
InChIKey	LDERDVMBIYGIOI-IZVMHKDJSA-N
PubChem CID	171397054

All values above are taken from PubChem CID 171397054 and can be checked against that record.

2D Structure

CHEMICAL IDENTIFIERS
CAS Number	1415456-99-3
PubChem CID	171397054
IUPAC Name	20-[[(1S)-4-[[(2S)-6-amino-1-[[(4R,7S,10S,13S,16S,19R)-4-[[(2S)-1-[[(2S,3R)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2R)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-4-amino-1-[[(2S)-1-[[2-[(2S)-2-[[(2S,3S)-1-[[(2R)-1-[(2R)-2-[(2R)-2-[[(2R,3S)-1-[[(2R)-4-amino-1-[[(2R)-1-[[2-[[(2R)-1-[[(2R)-4-amino-1-[[(2R,3S)-1-[(2R)-2-carbamoylpyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]-16-(2-amino-2-oxoethyl)-7,13-bis[(1R)-1-hydroxyethyl]-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxohexan-2-yl]amino]-1-carboxy-4-oxobutyl]amino]-20-oxoicosanoic acid
InChIKey	`LDERDVMBIYGIOI-IZVMHKDJSA-N`
InChI	InChI=1S/C194H312N54O59S2/c1-19-100(10)151(184(298)233-128(78-98(6)7)189(303)248-75-49-60-137(248)190(304)247-74-48-59-136(247)182(296)243-155(107(17)255)187(301)232-127(86-143(201)262)173(287)238-150(99(8)9)183(297)210-88-146(265)218-129(90-249)176(290)230-126(85-142(200)261)175(289)244-156(108(18)256)191(305)246-73-46-57-134(246)157(202)271)239-181(295)135-58-47-72-245(135)147(266)89-211-161(275)120(79-109-50-36-34-37-51-109)225-171(285)123(82-139(197)258)228-172(286)124(83-140(198)259)229-177(291)130(91-250)235-178(292)131(92-251)234-170(284)122(81-111-87-207-95-212-111)227-164(278)114(56-45-71-209-194(205)206)221-168(282)119(77-97(4)5)224-169(283)121(80-110-52-38-35-39-53-110)226-166(280)116(65-68-149(269)270)219-158(272)101(11)213-167(281)118(76-96(2)3)223-163(277)113(55-44-70-208-193(203)204)220-165(279)115(63-66-138(196)257)222-186(300)153(105(15)253)240-159(273)102(12)214-179(293)132-93-308-309-94-133(180(294)231-125(84-141(199)260)174(288)242-152(104(14)252)185(299)215-103(13)160(274)241-154(106(16)254)188(302)237-132)236-162(276)112(54-42-43-69-195)216-145(264)67-64-117(192(306)307)217-144(263)61-40-32-30-28-26-24-22-20-21-23-25-27-29-31-33-41-62-148(267)268/h34-39,50-53,87,95-108,112-137,150-156,249-256H,19-33,40-49,54-86,88-94,195H2,1-18H3,(H2,196,257)(H2,197,258)(H2,198,259)(H2,199,260)(H2,200,261)(H2,201,262)(H2,202,271)(H,207,212)(H,210,297)(H,211,275)(H,213,281)(H,214,293)(H,215,299)(H,216,264)(H,217,263)(H,218,265)(H,219,272)(H,220,279)(H,221,282)(H,222,300)(H,223,277)(H,224,283)(H,225,285)(H,226,280)(H,227,278)(H,228,286)(H,229,291)(H,230,290)(H,231,294)(H,232,301)(H,233,298)(H,234,284)(H,235,292)(H,236,276)(H,237,302)(H,238,287)(H,239,295)(H,240,273)(H,241,274)(H,242,288)(H,243,296)(H,244,289)(H,267,268)(H,269,270)(H,306,307)(H4,203,204,208)(H4,205,206,209)/t100-,101+,102-,103-,104+,105+,106+,107-,108-,112-,113-,114-,115-,116-,117-,118+,119-,120-,121-,122-,123-,124-,125-,126+,127+,128+,129+,130-,131-,132-,133-,134+,135-,136+,137+,150+,151-,152-,153-,154-,155+,156+/m0/s1
SMILES	CC[C@H](C)[C@@H](C(=O)N[C@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)N2CCC[C@@H]2C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(=O)N)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](CC(=O)N)C(=O)N[C@H]([C@H](C)O)C(=O)N3CCC[C@@H]3C(=O)N)NC(=O)[C@@H]4CCCN4C(=O)CNC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC6=CNC=N6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@@H]8CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N8)[C@@H](C)O)C)[C@@H](C)O)CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)CC[C@@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCCCC(=O)O

Identifiers retrieved from PubChem CID 171397054.

Certificate of analysis Sample lot

Cagrilintide

Lot: DL26082102
SKU: GD-CAGR
Manufactured: 21 Aug 2026
Retest: 21 Aug 2028

99.23% purity by HPLC

ConformsIdentity by MS

0.77%Total impurities

0.34%Largest single impurity

88.33%Peptide content

Reported composition each test reported separately, not a mass balance

Purity by HPLC 0.34%

Peptide content 88.33%

Water 4.83%

Total impurities 0.77%

Every figure is the result printed on the certificate. Purity is by HPLC area integration and the others are separate determinations on the same lot, so they are shown as separate bars rather than as shares of one total.

Test results as reported

#	Test	Specification	Result
1	Appearance	White or almost white powder	Conforms
2	Related substances: total impurities	≤1.0%	0.77%
3	Related substances: maximum single impurity	≤0.5%	0.34%
4	Identification by MS	4409.07 ± 4	Conforms
5	Water content (Karl Fischer)	≤8.0%	4.83%
6	Peptide purity (by HPLC)	≥99.0%	99.23%
7	Peptide content	≥80.0%	88.33%
8	Solubility	Soluble in water	Conforms
9	Bacterial endotoxins	≤10 EU/mg	Conforms
10	Residual solvent: methylene chloride	≤600 ppm	N.D
11	Residual solvent: acetonitrile	≤410 ppm	122 ppm
12	Residual solvent: methanol	≤3000 ppm	N.D
13	Residual solvent: N,N-dimethylformamide	≤880 ppm	N.D
14	Counter-ion: trifluoroacetate	≤1000 ppm	N.D
15	Counter-ion: phosphate	≤1000 ppm	N.D
16	Counter-ion: chloride	≤1000 ppm	N.D
17	Counter-ion: acetic acid	≤8.0%	6.51%
18	Escherichia coli	Not detected	Conforms
19	Pseudomonas aeruginosa	Not detected	Conforms
20	Salmonella	Not detected	Conforms
21	Microbial limits: TAMC	≤1000 cfu/g	Conforms
22	Microbial limits: TYMC	≤100 cfu/g	Conforms

Identity verified against PubChem, not a measurement of this lot

CAS number: 1415456-99-3
Molecular formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
Molecular weight: 4409.0 g/mol
Monoisotopic mass: 4406.2515 Da
InChIKey: LDERDVMBIYGIOI-IZVMHKDJSA-N
PubChem CID: 171397054

Corrections and queries 1 corrected, 1 queried with the supplier

Field	On the supplier document	Here	Why
Microbial test name	Escherichia Coil	Escherichia coli	Spelling.
Identity by MS	Conforms, with no observed mass	shown as reported, queried	The report gives the target 4409.07 +/- 4 and the word Conforms, but no measured mass. We have asked for the observed value.

A measured result is never rewritten. Where a reported figure does not stand up, it is shown as printed and marked as queried.

Sample lot. This is the report supplied with the sample of this compound. A production lot ships with its own report, published here in the same form and indexed by its own lot number.

Every analytical figure above is transcribed from the supplier’s report for lot DL26082102. Identity is the PubChem record, which can be checked independently. Purity is the main peak’s share of integrated peak area at the detection wavelength, so it measures related impurities. Water, salts and counter-ions are not part of it. These are the supplier’s release documents, not independent third-party tests.

This product is sold exclusively for in vitro and laboratory research use. It has not been evaluated by the FDA. Not approved for diagnostic, therapeutic, or veterinary use.

Cagrilintide

2D Structure

Reported composition each test reported separately, not a mass balance

Test results as reported

Identity verified against PubChem, not a measurement of this lot

Corrections and queries 1 corrected, 1 queried with the supplier

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