MT2

Name: MT2
Brand: GenDarwin Research
SKU: GD-MT2
Price: 59.00 USD
Availability: BackOrder

Melanotan II — Cyclic Heptapeptide α-MSH Analogue [Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-Lys)-NH₂]

$59.00 $5.90 / mg On backorder — dispatches in 5–10 business days

Lyophilized powder HPLC purity 98.80% Research use only

Melanotan II (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂) is a synthetic cyclic lactam heptapeptide analogue of α-MSH featuring norleucine at position 4, D-phenylalanine at position 7, and an Asp–Lys lactam bridge conferring conformational rigidity and enhanced metabolic stability. It functions as a non-selective agonist at MC1R, MC3R, MC4R, and MC5R, activating adenylyl cyclase and cAMP accumulation. Research has employed MT-II in melanocortin receptor binding kinetics assays, transcriptional regulation of melanogenesis in B16 cell models, and MC4R-dependent neuropeptide signalling network characterisation.

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PROPERTIES
Molecular Formula	C₅₀H₆₉N₁₅O₉
Molecular Weight (g/mol)	1024.2
Monoisotopic Mass (Da)	1023.5403
Topological Polar Surface Area (Å²)	385
Complexity	1950
XLogP (octanol-water partition)	0
Heavy Atom Count	74
H-Bond Donor Count	13
H-Bond Acceptor Count	11
Rotatable Bond Count	17
InChIKey	JDKLPDJLXHXHNV-MFVUMRCOSA-N
PubChem CID	92432

All values above are taken from PubChem CID 92432 and can be checked against that record.

2D Structure

CHEMICAL IDENTIFIERS
CAS Number	121062-08-6
PubChem CID	92432
IUPAC Name	(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
InChIKey	`JDKLPDJLXHXHNV-MFVUMRCOSA-N`
InChI	`InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1`
SMILES	`CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C`

Identifiers retrieved from PubChem CID 92432.

HPLC purity report Sample lot

MT2

Lot: P260724-LR052189
SKU: GD-MT2

98.80% main peak, area %

12.253 minMain peak retention

1.1902%All other peaks

0.6745%Largest single impurity

5Peaks integrated

Drawn from the integration table below. Each peak sits at its reported retention time and is scaled so its height and area match the report; the peak shape is modelled and the baseline is flat, so this represents the reported integration rather than the raw detector file. Only the peaks the report lists are drawn. The lighter trace is the same data at 5× vertical zoom, because the impurity peaks are a fraction of a percent of the main peak.

Integration table as reported

#	Ret. time	Height	Area	Area %
1	9.470	1686.884	16425.900	0.1338
2	10.458	634.928	6691.551	0.0545
3	12.083	17046.740	40194.969	0.3274
4	12.253	309824.813	12132241.000	98.8099
5	12.253	19231.615	82815.945	0.6745

Retention time in minutes. Height and area are the report’s own values and units. Method wording is normalised for units and spelling; every value is as reported.

Method as reported

Column	Xbridge BEH130 C18, 4.6 × 250 mm, 5 µm
Mobile phase A	0.1% trifluoroacetic acid in acetonitrile
Mobile phase B	0.1% trifluoroacetic acid in water
Flow rate	1.0 mL/min
Detection	220 nm
Injection volume	20 µL

Time	A	B
0.0min	30%	70%
25.0min	55%	45%
25.1min	100%	0%
30.0min	Stop

Identity verified against PubChem, not a measurement of this lot

CAS number: 121062-08-6
Molecular formula: C₅₀H₆₉N₁₅O₉
Molecular weight: 1024.2 g/mol
Monoisotopic mass: 1023.5403 Da
InChIKey: JDKLPDJLXHXHNV-MFVUMRCOSA-N
PubChem CID: 92432

Corrections and queries 0 corrected, 1 queried with the supplier

Field	On the supplier document	Here	Why
Peak table	peaks 4 and 5 both at 12.253 min	shown as reported, queried	As above: one peak split by the software. The split lowers the reported purity, so the published figure is the conservative one.

A measured result is never rewritten. Where a reported figure does not stand up, it is shown as printed and marked as queried.

Sample lot. This is the report supplied with the sample of this compound. A production lot ships with its own report, published here in the same form and indexed by its own lot number.

Every analytical figure above is transcribed from the supplier’s report for lot P260724-LR052189. Identity is the PubChem record, which can be checked independently. Purity is the main peak’s share of integrated peak area at the detection wavelength, so it measures related impurities. Water, salts and counter-ions are not part of it. These are the supplier’s release documents, not independent third-party tests.

This product is sold exclusively for in vitro and laboratory research use. It has not been evaluated by the FDA. Not approved for diagnostic, therapeutic, or veterinary use.

MT2

2D Structure

Integration table as reported

Method as reported

Identity verified against PubChem, not a measurement of this lot

Corrections and queries 0 corrected, 1 queried with the supplier

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