Thymalin

Name: Thymalin
Brand: GenDarwin Research
SKU: GD-THYM
Price: 69.00 USD
Availability: BackOrder

Thymulin (FTS) — Zinc-Dependent Thymic Nonapeptide (Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn)

$69.00 $13.80 / mg On backorder — dispatches in 5–10 business days

Lyophilized powder HPLC purity 98.46% Research use only

Thymalin (Thymulin; FTS; Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn) is a synthetic nonapeptide corresponding to the serum thymic factor from porcine thymic epithelial cells. The N-terminal pyroglutamic acid residue confers aminopeptidase resistance. Full biological activity requires stoichiometric Zn²⁺ chelation (1:1), forming a complex that engages T-lymphocyte surface receptors. Research has characterised Thymalin-associated T-lymphocyte differentiation, CD4⁺/CD8⁺ dynamics, cytokine regulation (IL-1, IL-2, IL-6, IFN-γ, TNF-α), NK cell activity, and geroprotective parameters including immunosenescence attenuation in longitudinal rodent model studies.

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PROPERTIES
Molecular Formula	C₃₃H₅₄N₁₂O₁₅
Molecular Weight (g/mol)	858.9
Monoisotopic Mass (Da)	858.3832
Topological Polar Surface Area (Å²)	452
Complexity	1610
XLogP (octanol-water partition)	-10.9
Heavy Atom Count	60
H-Bond Donor Count	15
H-Bond Acceptor Count	16
Rotatable Bond Count	28
InChIKey	LIFNDDBLJFPEAN-BPSSIEEOSA-N
PubChem CID	3085284

All values above are taken from PubChem CID 3085284 and can be checked against that record.

2D Structure

CHEMICAL IDENTIFIERS
CAS Number	63958-90-7
PubChem CID	3085284
IUPAC Name	(2S)-4-amino-2-[[(2S)-2-[[2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid
InChIKey	`LIFNDDBLJFPEAN-BPSSIEEOSA-N`
InChI	`InChI=1S/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1`
SMILES	`C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@@H]1CCC(=O)N1`

Identifiers retrieved from PubChem CID 3085284.

HPLC purity report Sample lot

Thymalin

Lot: P260706-LR407053
SKU: GD-THYM

98.46% main peak, area %

13.297 minMain peak retention

1.5372%All other peaks

0.8853%Largest single impurity

3Peaks integrated

Drawn from the integration table below. Each peak sits at its reported retention time and is scaled so its height and area match the report; the peak shape is modelled and the baseline is flat, so this represents the reported integration rather than the raw detector file. Only the peaks the report lists are drawn. The lighter trace is the same data at 20× vertical zoom, because the impurity peaks are a fraction of a percent of the main peak.

Integration table as reported

#	Ret. time	Height	Area	Area %
1	13.093	15183.041	75651.633	0.8853
2	13.297	736504.313	8413682.000	98.4628
3	13.297	5459.649	55703.289	0.6519

Retention time in minutes. Height and area are the report’s own values and units. Method wording is normalised for units and spelling; every value is as reported.

Method as reported

Column	250 × 4.6 mm, Kromasil-C18-5 µm
Mobile phase A	0.1% TFA in water
Mobile phase B	0.1% TFA in acetonitrile
Flow rate	1.0 mL/min
Detection	220 nm
Injection volume	10 µL

Time	A	B
0.1min	98%	2%
25.0min	73%	27%
25.1min	0%	100%
30.0min	Stop

Identity verified against PubChem, not a measurement of this lot

CAS number: 63958-90-7
Molecular formula: C₃₃H₅₄N₁₂O₁₅
Molecular weight: 858.86 g/mol
Monoisotopic mass: 858.3832 Da
InChIKey: LIFNDDBLJFPEAN-BPSSIEEOSA-N
PubChem CID: 3085284

Corrections and queries 0 corrected, 1 queried with the supplier

Field	On the supplier document	Here	Why
Peak table	peaks 2 and 3 both at 13.297 min	shown as reported, queried	As above: one peak split by the software, which lowers rather than raises the reported purity.

A measured result is never rewritten. Where a reported figure does not stand up, it is shown as printed and marked as queried.

Sample lot. This is the report supplied with the sample of this compound. A production lot ships with its own report, published here in the same form and indexed by its own lot number.

Every analytical figure above is transcribed from the supplier’s report for lot P260706-LR407053. Identity is the PubChem record, which can be checked independently. Purity is the main peak’s share of integrated peak area at the detection wavelength, so it measures related impurities. Water, salts and counter-ions are not part of it. These are the supplier’s release documents, not independent third-party tests.

This product is sold exclusively for in vitro and laboratory research use. It has not been evaluated by the FDA. Not approved for diagnostic, therapeutic, or veterinary use.

Thymalin

2D Structure

Integration table as reported

Method as reported

Identity verified against PubChem, not a measurement of this lot

Corrections and queries 0 corrected, 1 queried with the supplier

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