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GenDarwin Research Mots-c lyophilized research peptide vial, CAS 1627580-64-6

98.32%HPLC purity, as reported for this lot

COAPublished for lot P240715-YS448144

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Mots-c

Name: Mots-c
Brand: GenDarwin Research
SKU: GD-MOTS
Price: 149.00 USD
Availability: BackOrder

Mitochondrial-Derived Peptide — MRWQEMGYIFYPRKLR (16-mer; 12S rRNA-encoded)

$79.00 $7.90 / mg On backorder — dispatches in 5–10 business days

Lyophilized powder HPLC purity 98.32% Research use only

MOTS-c is a 16-amino-acid mitochondria-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. It activates AMPK via inhibition of AICAR transformylase (ATIC) in the folate-methionine cycle, modulates FOXO1-dependent transcription, and translocates to the nucleus under metabolic stress. Research models have characterised MOTS-c in skeletal muscle insulin sensitisation, adipose tissue metabolic regulation, mitochondrial biogenesis, oxidative stress resistance, and overlap with exercise-induced molecular signalling cascades.

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PROPERTIES
Molecular Formula	C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight (g/mol)	2174.6
Monoisotopic Mass (Da)	2173.1077
Topological Polar Surface Area (Å²)	890
Complexity	4510
XLogP (octanol-water partition)	-3.9
Heavy Atom Count	153
H-Bond Donor Count	31
H-Bond Acceptor Count	29
Rotatable Bond Count	73
InChIKey	WYTHCOXVWRKRAH-LOKRTKBUSA-N
PubChem CID	146675088

All values above are taken from PubChem CID 146675088 and can be checked against that record.

2D Structure

CHEMICAL IDENTIFIERS
CAS Number	1627580-64-6
PubChem CID	146675088
IUPAC Name	(4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
InChIKey	`WYTHCOXVWRKRAH-LOKRTKBUSA-N`
InChI	InChI=1S/C101H152N28O22S2/c1-7-57(4)83(96(148)126-76(50-58-19-9-8-10-20-58)92(144)127-78(52-60-30-34-63(131)35-31-60)97(149)129-46-18-27-79(129)95(147)122-69(25-16-44-112-100(107)108)86(138)118-67(23-13-14-42-102)87(139)124-74(49-56(2)3)91(143)123-73(98(150)151)26-17-45-113-101(109)110)128-94(146)75(51-59-28-32-62(130)33-29-59)116-81(133)55-115-85(137)72(41-48-153-6)121-90(142)71(37-39-82(134)135)119-89(141)70(36-38-80(104)132)120-93(145)77(53-61-54-114-66-22-12-11-21-64(61)66)125-88(140)68(24-15-43-111-99(105)106)117-84(136)65(103)40-47-152-5/h8-12,19-22,28-35,54,56-57,65,67-79,83,114,130-131H,7,13-18,23-27,36-53,55,102-103H2,1-6H3,(H2,104,132)(H,115,137)(H,116,133)(H,117,136)(H,118,138)(H,119,141)(H,120,145)(H,121,142)(H,122,147)(H,123,143)(H,124,139)(H,125,140)(H,126,148)(H,127,144)(H,128,146)(H,134,135)(H,150,151)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t57-,65-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,83-/m0/s1
SMILES	`CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)N`

Identifiers retrieved from PubChem CID 146675088.

Certificate of analysis Sample lot

Mots-c

Lot: P240715-YS448144
SKU: GD-MOTS
Manufactured: 15 Aug 2026
Retest: 15 Aug 2028

98.32% purity by HPLC

2173.65Identity by MS

1.68%Total impurities

0.88%Largest single impurity

83.51%Peptide content

Reported composition each test reported separately, not a mass balance

Purity by HPLC 98.32%

Peptide content 83.51%

Water 4.5%

Acetate 14.1%

Total impurities 1.68%

Largest single impurity 0.88%

Every figure is the result printed on the certificate. Purity is by HPLC area integration and the others are separate determinations on the same lot, so they are shown as separate bars rather than as shares of one total.

Test results as reported

#	Test	Specification	Result
1	Appearance	White powder	White powder
2	Solubility	Soluble in water or acetic acid to give a clear, colourless solution	Conforms
3	Identification (MS)	2174.59 ± 1.0	2173.65
4	Amino acid composition	±10% of theoretical	Conforms
5	Peptide purity (by HPLC)	≥98.0% by area integration	98.32%
6	Related substances (HPLC): total impurities	≤2.0%	1.68%
7	Related substances (HPLC): largest single impurity	≤1.0%	0.88%
8	Acetate content (by HPLC)	≤15.0%	14.1%
9	Water content (Karl Fischer)	≤8.0%	4.5%
10	Peptide content (N determination)	≥80.0%	83.51%
11	Assay (anhydrous, acetic-acid-free)	95.0–105.0%	102.11%

Identity verified against PubChem, not a measurement of this lot

CAS number: 1627580-64-6
Molecular formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight: 2174.6 g/mol
Monoisotopic mass: 2173.1077 Da
InChIKey: WYTHCOXVWRKRAH-LOKRTKBUSA-N
PubChem CID: 146675088

Corrections and queries 2 corrected, 1 queried with the supplier

Field	On the supplier document	Here	Why
Test numbering	ten numbered rows, with two results under row 6	renumbered in sequence	Row 6, Related Substance, carries two separate limits and two separate results. They are listed as separate tests here, so every row after it shifts up by one against the document's numbering.
Solubility specification	Soluble in water or acetic acid at a to give a clear, colorless solution	Soluble in water or acetic acid to give a clear, colourless solution	Wording only. The stray 'at a' is a typing error in the supplier's template; the result, Conforms, is unchanged.
Assay result	102.11%	shown as reported, queried	102.11% is exactly peptide content 83.51% + acetate 14.1% + water 4.5%, an arithmetic sum rather than an anhydrous, acetate-free assay. The same 102.11% appears on this supplier's Semax certificate from the same arithmetic. A measured result is not ours to rewrite, so it stands as printed and we have asked the supplier to correct it.

A measured result is never rewritten. Where a reported figure does not stand up, it is shown as printed and marked as queried.

Sample lot. This is the report supplied with the sample of this compound. A production lot ships with its own report, published here in the same form and indexed by its own lot number.

Every analytical figure above is transcribed from the supplier’s report for lot P240715-YS448144. Identity is the PubChem record, which can be checked independently. Purity is the main peak’s share of integrated peak area at the detection wavelength, so it measures related impurities. Water, salts and counter-ions are not part of it. These are the supplier’s release documents, not independent third-party tests.

This product is sold exclusively for in vitro and laboratory research use. It has not been evaluated by the FDA. Not approved for diagnostic, therapeutic, or veterinary use.

Mots-c

2D Structure

Reported composition each test reported separately, not a mass balance

Test results as reported

Identity verified against PubChem, not a measurement of this lot

Corrections and queries 2 corrected, 1 queried with the supplier

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